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This dysregulation orchestrates a symphony of cellular responses, including activation of oxidative stress, impairment of the ubiquitin-proteasome system and activation of protein toxicity stress responses, all of which converge to regulate cell death

Nitric oxide (NO) signaling cascade The generation of nitric oxide (NO) catalyzed by endothelial nitric oxide synthase (eNOS) plays a critical role in protecting the vascular endothelium from oxidative and inflammatory insults (27)