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Concentrations vary widely based on study design, experimental endpoints, and research model selection

Some of the most commonly reported adverse effects with these new therapies are cutaneous, and can potentially limit the use of these agents and add cost to already expensive treatment regimens.1 It is important for physicians and other healthcare providers to be aware of these effects, have a basic understanding of how to manage patients with these reactions, and to know when to refer to a dermatologist

The dramatic reduction in caloric intake necessarily decreases available energy