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FIGURE 3 4.2.2 ABC transporter mediated drug efflux ABC transporters utilize ATP hydrolysis to efflux gemcitabine and its metabolites from cells, thereby reducing intracellular drug concentrations and contributing to resistance

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4, 5 Among the growth factors involved in the proliferation step, hepatocyte growth factor (HGF), transforming growth factor alpha (TGF ) and epidermal growth factor (EGF) induce hepatocytes to override the mitogen restriction point located at 2/3 of G1 phase

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However, DHLA and DHLA-Ala both acts as stabilizing agents due to their bidentate feature to form stable DHLA and DHLA-Ala capped gold nanoparticles (DHLA@Au NPs and DHLA-Ala@Au NPs)