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Its deficiency, although rare, may present with dermatitis, brittle nails, and hair loss (248)

The exact mechanisms of pathogenesis of this disorder are not clear yet, however some factors are shown to be associated with depression progression including genetic factors and non-genetic factors [39]

Male infertility is occasionally brought on by OS, which results from an unbalance in antioxidants and ROS and leads to excessive SDF and aberrant semen parameters

doi: 10.1038/nn.4476 63 Garca-ClosasM.MalatsN.SilvermanD.DosemeciM.KogevinasM.HeinD

Hage DS, Anguizola JA, Bi C, Li R, Matsuda R, Papastavros E, Pfaunmiller E, Vargas J, Zheng X