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By enhancing intracellular hydroperoxides, especially hydrogen peroxide, decreasing reduced glutathione concentration, increasing cysteine oxidation, and activating protein kinases, oxidant stress can enhance the activity of transcription factors, such as the nuclear factor kappa B and activator protein-1, which are involved in the expression of cell surface adhesion molecules, growth factors, immunoreceptors, and cytokines

The mass spectrometer then fragments and measures ions by mass-to-charge ratio

p53 also impacts insulin sensitivity via autocrine loops and the autonomous regulation of cells

Nicotinamide adenine dinucleotide (NAD + ) serves as a central metabolic cofactor and essential substrate for a number of intracellular enzymes that regulate critical biological processes