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Glutamine synthesis is driven by an ATP-dependent glutamine synthetase (GS) that produces glutamine from glutamate and ammonia

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We have identified trimetazidine as a candidate to treat bipolar depression [19] using an in silico treatment discovery model in diabetes [18] that led to a successful Phase 2 clinical trial to treat diabetes [115]

In addition, none of polysorbate 80, CAT, and 3-AT affected the cell viability, intracellular ROS, LDH release, and MDA levels of macrophage, when they were used separately (as shown in Fig