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210 In a randomized, double-blind, placebo-controlled trial that included 81 healthy subjects, those who received 400 mg ebselen twice daily for four days, beginning two days before testing, exhibited 68% less of a temporary decrease in hearing 15 minutes after an experimental loud sound exposure compared with placebo

Organs such as brain and heart, with high rates of oxygen consumption and limited respiration levels, are particularly vulnerable to this phenomenon, hence partially explaining the high prevalence of cardiovascular diseases (CVD) and neurological disorders in elderly (Corbi et al., 2008)

In the bacterial community, core microbiota such as Firmicutes and Bacteroidetes are reduced, while Proteobacteria, including Escherichia-Shigella and Enterococcus, are significantly enriched [93, 94, 96]

The Wald test was used to determine Fishers z value, and the combined results were shown as estimates

Numerical and graphical optimization were employed for identifying the optimized composition