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In addition, the pandemic led to lifestyle changes in different parts of the world (lockdowns, changes in diet, hygiene), which could affect the outcomes

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Gomes et al 3 showed that, compared to nonmetastatic breast cancer cells, metastatic breast cancer cells downregulate an enzyme of the propionate metabolism pathway, methylmalonyl-CoA epimerase, which leads to an intracellular accumulation of MMA and fuels metastasis