ishigaki l glutathione review 2016

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Nature 403 , 4145 (2000)

System Xc-GSH-GPX4 axis The cystine/glutamate antiporter (System Xc-) transports glutamate out of the cell and transports cystine into the cell, where the transported cystine is reduced to cysteine (Parker et al., 2021) and then combined with glutamate and glycine in the presence of glutathione synthetase (Wu et al., 2022) (GPX4 is a selenocysteine-containing and GSH-dependent enzyme that is a key regulator of Ferroptosis (Seibt et al., 2019)