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There is a strong evidence that the GSTM1 null genotype increases the risk of adverse effects from cyclophosphamide, regardless of other patient characteristics (age, gender, kidney function, and total CYC dose), with the odds ratio was 3.345, compared to those with functioning GSTM1 gene ( GSTM1 null genotype and increased CYC-related adverse effects, particularly when adjusted for clinical variables, others have found no relationship in the context of short-term high-dose regimens ( GSTP1 gene encodes glutathione S-transferase Pi 1, an enzyme involved in the phase II detoxification of reactive drug metabolites, including those generated during cyclophosphamide (CYC) metabolism

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Hydration: Glutathione helps the liver process waste, and water is the vehicle that moves that waste out of the body

Causes precipitation or coagulation of proteins

However, the TLR2 pep-orid-liposome showed the best killing effect due to AML specific delivery via TLR2 peptide