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5-Amino-1MQ functions as a small-molecule inhibitor of NNMT, the enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide, producing 1-methylnicotinamide

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Here we demonstrate that deletion of rv1127c results in dysregulated CCM, disruption in both redox balance and in bioenergetics, when grown on propionate-containing, or yielding medium, and reduced survival and virulence of Mtb in two different murine models of TB