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Indeed, after introduction of HAART to treat HIV-1 infection, it quickly became apparent that mitochondrial toxicity is a major reason for antiretroviral-related adverse events (Brinkman et al., 1998)

(395), the topical application of resveratrol-loaded lipid nanocarriers significantly improved skin hydration, emphasizing the potential of lipid-based delivery systems in skincare

Iron plays a central role in these processes, primarily through the Fenton/Haber-Weiss reaction, which generates hydroxyl radicals that drive cholesterol oxidation and lipid peroxidation [48]

Vallerga CLF, Zhang J, Fowdar, et al

While this effect was observed in a viral model, it suggests that loss of antioxidant capacity may confer an advantage in tissue environments, with implications for solid tumors