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Minimal adverse effects observed in preclinical models

All three pathways are known regulators of T cell metabolism [144,145,146]

Al-BahlaniSAl-LawatiHAl-AdawiMAl-AbriNAl-DhahliBAl-AdawiKet al

PUMA mediates cell apoptosis in response to the tumor necrosis factor (TNF)-related apoptosis-inducing ligand and ferroptosis inducers, and p53 may regulate ferroptosis and apoptosis as a key factor in the crosstalk of the two death mechanisms through PUMA regulation (74)

Those with active or recent pancreatic issues should be cautious with Retatrutide, as all incretin-based therapies carry theoretical (though rare) pancreatitis risk