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Metformin enhances neuroprotective brain-derived neurotrophic factor (BDNF) leading to the inhibition of neuroinflammation and oxidative stress-induced neuronal injury

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Through structural optimization, SRT2104 significantly improves bioavailability, exerts pharmacological activity at lower doses, and demonstrates high specificity in activating SIRT1, avoiding the multi-target confounding effects of resveratrol