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A landmark 2018 genomics study found GHK-Cu capable of influencing over 4,000 human genes

In another field, in vitro studies have demonstrated that treatment with plant extracts of Atractylodes macrocephala (AM) or Taraxacum herba (TH) increased HMOX1 production

doi: 10.1016/j.psychres.2016.05.013 169 VaivaG.ThomasP.DucrocqF.FontaineM.BossV.DevosP.et al

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Mechanistically, A5 suppresses HMGB1/NF-B signaling, activates the Nrf2/HO-1 pathway, promotes anti-inflammatory M2 microglial polarization, and limits peripheral immune infiltration, collectively reducing ferroptosis and secondary injury ( 3.3.2 Neurodegenerative diseases 3.3.2.1 Alzheimers disease (AD) and Parkinsons disease (PD) Ferroptosis is increasingly implicated in the progression of Alzheimers disease (AD) and Parkinsons disease (PD) ( TFRC and ALOXE3 to enhance iron accumulation and lipid peroxidation (Wu et al., 2023)