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They are seen in certain strains of mice and have also been induced by certain hepatocarcinogens (Diwan, Ward, and Rice 1989)

doi: 10.1111/eth.12642 61 ONeillS

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TROPION-Lung05 phase II trial has evaluated Dato-DXd in 137 patients with oncogenic addition NSCLC (including EGFR , ALK , ROS1 , NTRK , BRAF , MET exon 14, and RET ) progressing to 1 targeted therapy and platinum-doublet chemotherapy