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Description

J Medicinal Chem (2022) 65(3):174966

Biotrophic pathogens rely on the apoplast for nutrients extracted from living cells (Kemen and Jones, 2012

However, intense signal stimulation by glutamate would produce excitotoxicity, leading to CNS damage (Rothman and Olney, 1986) via excessive Ca 2+ entry (Choi, 1987)

Conversely, long-term (chronic) exposure to heavy metal toxicity may lead to hyperactivation of Nrf2, which is associated with increased cell division and ultimately carcinogenesis