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In practice, BPC-157 is most commonly combined with: TB-500: Works through the actin-sequestration pathway rather than VEGF, making the two mechanistically complementary for tissue repair GHK-Cu: Copper peptide with documented effects on collagen remodelling and wound repair, often considered when skin and connective tissue quality are part of the picture Stacking should serve a clear clinical rationale

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Organizes newly formed collagen during injury repair, preventing fibrosis and ensuring new tissue is highly elastic and resilient

Response: As we noted in the CY 2026 OPPS/ASC proposed rule (90 FR 33774), while REHs may have some familiarity and experience with reporting eCQMs when formerly operating as a subsection (d) hospital or a CAH participating in the Medicare Promoting Interoperability Program, we recognize that technological, monetary, and staffing barriers may present challenges to eCQM adoption and use in some REHs

doi: 10.1371/journal.ppat.1000911 268 SaleemM.PrinceS