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CYP2D6*10 and *41 have reduced enzymatic activity, whereas CYP2D6*3 , *4 , and *5 have no enzymatic activity

The severity of the allopurinol hypersensitivity syndrome is a reminder that specific criteria must be used to decide which patients should be treated with allopurinol (See Table 4: Reasons to Use Medication to Lower Uric Acid )

That makes them both powerful and safe when used correctly

Although various carriers have been exploited for delivery of neurotherapeutics, target-orientated nanotherapeutic delivery is more precise for brain targeting

This process not only impairs cellular energy metabolism but also exacerbates oxidative stress, further contributing to neuronal death (12,13)