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Another study also elucidated that AARS1 can function as a lactate sensor, catalyzing the generation of lactate-AMP, and mediating the lactylation of p53, and the lactylation of p53 will inhibit its liquid-liquid phase separation, DNA binding capabilities, and ultimately lead to a decrease in transcriptional activity, fostering the onset and development of tumors

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Current research has not yet fully elucidated why TINs exhibit both susceptibility and resistance to ferroptosis across different tumor types or even within the same tumor model

Binding of AngII to its AT1 receptor leads to the activation of MAP kinases, phosphorylation of tyrosine kinases and production of ROS, all of which induce VSMC proliferation

( 2 O 2 and induced by Zn stress (Tsuji et al., 2002), indicating that exogenous GSH-induced PCs may be directly involved in the removal of ROS in Cd-exposed plants