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G., Braulke, T., Hartmann, H

but with caution due to alpha receptor blocking action that can cause severe hypotension & sinus tachycardia The elimination half-life is 6-8 hours in adults and 3-4 hours in children Drug interactions: drugs that alkalinize the urine (Na bicarb) will increase elimination & thereby reduce drug effect quinidine levels are increased by coadministration of amiodarone or cimetidine hepatic elimination is increased by drugs that induce P450 3A4 (phenobarbital, phenytoin & rifampin) Quinidine decreases the clearance & increases the Vd of , resulting in a ~doubling of digoxin plasma levels digoxin Quinidine's anticholinergic, vasodilating, and negative inotropic actions may be additive to those of other drugs References: Harvey RD, Grant AO (2021): Agents used in cardiac arrhythmias (Chapter 14)

This pulse can last for up to 3 hours after the administration of this dose

What could delay approval is if the remaining TRIUMPH trials show higher rates of dysesthesia, more severe cases, or unexpected long-term consequences