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In addition, NRF2 can also regulate the transcriptional expression of metabolites involved in intermediate metabolism, some of which play essential roles in the regeneration of NADPH, a key electron donor needed to reduce oxidative substrates [108]

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He also assessed patients for their fibromyalgia-like score

An appropriate ROS concentration is conducive to normal angiogenesis and vascular homeostasis, while a high concentration of ROS chronically induces ferroptosis and consequently causes pathological damage to blood vessels