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The co-cultures were incubated on an orbital shaker set at a speed of 150 rpm, 30 C, under a light intensity of ~ 20 mol m 2 s 1

One is that GSSG and GS-X produced in cardiomyocytes are pumped out by multidrug resistance protein 1 (MRP1), preventing GSSG or GS-X accumulation in cardiomyocytes [33, 34], and subsequently enter the -glutamyl cycle