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Stearoyl-CoA desaturase-1 impairs the reparative properties of macrophages and microglia in the brain

Based on the spectrum of their biological activity, natural products are considered attractive

Another practical problems facing 3BP in clinical oncology is its fast catabolism using glutathione conjugation that impairs its use 22

Furthermore, the long non-coding (lnc)RNA KCTD21-AS1, modified by METTL14-mediated N6-methyladenosine methylation, acts as a competing endogenous RNA for miR-519d-5p to regulate CD47 and TIPRL expression, thereby modulating macrophage phagocytosis and autophagy in LC cells (24)

Classification and chemical structures of ADC linkers [2] As of December 2025, 21 ADCs have received global approval (Table 1)