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There is evidence that hepatic encephalopathy may result in part from the action of endogenous substances that bind to the GABAbenzodiazepine receptor complex in the brain

Seah I, Zhao X, Lin Q, Liu Z, Su SZZ, Yuen YS, et al

The Crucial Role of the Blood-Brain Barrier in Neurodegenerative Diseases: Mechanisms of Disruption and Therapeutic Implications

however, p38 MAPK exerts a positive regulation on PGC1, and MAPK1 along with MAPK14 promote both starvation- and hypoxia-induced mitophagy in HeLa cells (Hirota et al., 2015)

Role of the CCL20/CCR6 axis in tubular epithelial cell injury: Kidney-specific translational insights from acute kidney injury to chronic kidney disease