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12 Fear of opioid withdrawal, particularly its undertreatment in the healthcare setting, has been a frequently reported reason for individuals delaying OUD treatment

This creates less tissue drag and a cleaner entry path

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A general decrease in mitochondrial mass and mitochondrial biogenesis also contributes to the decreased oxidative capacity in the failing heart, partly due to the decrease in PGC-1 and its transcription cascade [132]

Aging and chronic ailments like diabetes decrease the ability of the kidneys to recover from injuries, resulting in chronic kidney disease (CKD)