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Ginsenoside Rc, the main active ingredient isolated from ginseng, increases the deacetylase activity of SIRT6, thereby decreasing the level of acetylated NRF2 and increasing the stability of NRF2, which in turn attenuates hepatocellular injury and oxidative stress in alcoholic liver disease [79]

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Base quality score recalibration was performed, and variants were called using HaplotypeCaller, with individuals called separately, as implemented by GATK