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[37] A mechanism was therefore proposed in which the side chain of a conserved glutamate residue, for example, Glu 59 in Bacillus stearothermophilus or Glu 51 in Saccharomyces uvarum (brewers yeast) pyruvate decarboxylase, donates a proton to the aminopyrimidine ring

The nomogram in the testing cohort also showed good prediction performance as the training one and the C-index was 0.706 (95% CI 0.6120.800)

By inhibiting epigenetic enzymes like DNMTs, compounds such as curcumin and apigenin reduce CpG hypermethylation in the NRF2 promoter, leading to elevated NRF2 levels and offering potential therapeutic benefits for diseases associated with oxidative stress [35, 149]

These quantitative boundaries are essential for achieving consistent AgNP morphology and have been incorporated into this revised review to enhance methodological rigor and reproducibility (Balamurugan et al., 2024