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In some cases, cellular structures resembling tactoid bodies can be found (Fig

Furthermore, iron-mediated epithelial cell death promotes the secretion of various pro-fibrotic factors such as TGF-, CTGF, etc., inducing proliferation and differentiation of interstitial fibroblasts, ultimately leading to renal fibrosis

The demonstrated synergistic potentiating of mercury toxicity by other heavy metals (lead, cadmium, silver, etc.) explains why a direct correlation between mercury levels alone and severity of AD-like brain damage is difficult to demonstrate