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When MUT activity is impaired due to genetic mutations or functional vitamin B12 deficiency, methylmalonyl-CoA cannot be efficiently converted into succinyl-CoA

This process doesnt require intrinsic factor, but it is very inefficientonly about 1% of the B12 you swallow is absorbed this way [7]

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B12 deficiency typically has two causes: malabsorption or inadequate intake

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