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1.4 Glucocorticoid-Induced Osteoporosis Reclast is indicated for the treatment and prevention of glucocorticoid-induced osteoporosis in men and women who are either initiating or continuing systemic glucocorticoids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who are expected to remain on glucocorticoids for at least 12 months [see Clinical Studies (14.4)]

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Q: Can I use it in soap

That's a flea bite compared to the cramping and burning when they put the B12 in, so I'm not going to worry about it

Decreased interstitial SA--gal activity and lowered levels of senescence-associated proteins p53, p21, and p16