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On average a 45-gram tube of tretinoin cream may last around six months if applied daily to your face and up to a year if you apply it every other day

Plant Cell Rep 36(6):791805

Lindenmaier Z, Ellegood J, Stuive M, Easson K, Yee Y, Fernandes D, et al

So the constraint applies to both molecules

Research links environmental exposure to TAO, where pollutants induce ROS through oxidation reactions, increasing intracellular oxidative stress (78, 79)