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Resistance to cisplatin and etoposide correlates with elevated ABCB1 expression

Elegant experiments revealed that much of the glutamine dependence of cancer cell lines is driven by the superphysiologic concentration of cystine in standard growth media: in these cells high cystine drives the cystine/glutamate antiporter xCT to import cystine and excrete glutamate, and the cells must then import glutamine to maintain intracellular glutamate

Al-Shobaili, H.A., et al.,Hydroxyl radical modification of immunoglobulin g generated cross-reactive antibodies: its potential role in systemic lupus erythematosus