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353 Interestingly, synovial inflammation is a key event in the RA pathogenesis and a critical trigger for destructions of bone and cartilage

In this review, we systematically analyzed and investigated the intricate biological behaviors associated with HGSOC drug resistance, which not only enhances the understanding of disease progression but also provides essential theoretical foundations for the development of more precise and effective targeted therapies

CXCL1 and CXCL2 released by KCs are confirmed to be pro-inflammatory chemokines which take responsible to disease exacerbation [51]

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In fact, in 2017 it was estimated that more than 2 million individuals had an opioid use disorder while 11 million people reported misusing opioids