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Oxygen deprivation (hypoxia) represents the immediate result, since intestinal cells are deprived of the oxygen necessary for mitochondrial oxidative phosphorylation, the major process for creating ATP (Weinberg et al., 2000

Non-canonical (non-SMAD2/3) TGF-beta signaling in fibrosis: Mechanisms and targets

On one side, peroxynitrite formation can be a mechanism to consume superoxide thereby protecting biomolecules from oxidation and preventing further ROS production (Kanner et al., 1991