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For example, though vitamin C is unlikely to cause toxicity in healthy people, it can lead to tissue damage and fatal heart abnormalities in those with hemochromatosis, an iron storage disorder ( Side effects related to overconsuming fat-soluble vitamins Because fat-soluble vitamins can accumulate in your bodys tissues, they can cause much more harm when taken at high doses, especially over long periods

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Safety/quality uncertainty can dominate the risk profile depending on sourcing

Future research should prioritize large, multicenter, rigorously designed RCTs with standardized outcomes, and efforts to publish both positive and negative findings are essential to establish a balanced evidence base