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After maintaining HT-22 cells in high glucose condition medium (100 mM), the cells were treated with anti-RGMa antibody for 3 h to inhibit the function of RGMa expressed on the cells

Mitochondrial cascade hypothesis Mitochondrial dysfunction and the accumulation of reactive oxygen species lead to neuronal damage and ultimately contribute to the pathogenesis of neurodegenerative diseases, particularly AD

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Insulin Resistance or Elevated Fasting Blood Glucose Cause : Chronic GH and IGF-1 elevation can blunt insulin sensitivity in some users, particularly at higher doses or during long cycles