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SRD5A1 was mainly expressed in the skin, scalp, liver, and brain tissues, while SRD5A2 was predominantly found in androgen target organs such as the prostate and genital skin, but only SRD5A1 was upregulated in prostate cancers 7,8

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The researchers observed that spadin might stimulate serotonin neurons and noted that the actions of spadin combined with serotonin agonists appeared additive, operating independently