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The pH is quickly neutralized following elution because antibodies are not stable long term in acidic conditions

(Springer, Cham: Springer Nature) 33745

and G.G

Taylor and Kirby, 2015

While most clinical evidence supports a favorable safety profile at typical therapeutic doses, caution is warranted as higher doses may cause sedation, cardiovascular effects such as hypotension and arrhythmias, and, in rare cases, respiratory depression