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Physical symptoms extend beyond neurological manifestations to include macrocytic anemia , where Red Blood cells become enlarged and inefficient at oxygen transport

For this reason, folic acid supplements may mask vitamin-B12-induced megaloblastic anemia and cause an underlying vitamin B12 deficiency to go undetected ( Megaloblastic anemia is a condition characterized by enlarged red blood cells

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For DNA to be replicated for new cells, both folate and vitamin B12 can be limiting factors

Their use-dependent binding increases affinity at higher heart rates, making them effective for ventricular arrhythmias (11)(12)