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doi: 10.1016/j.cmet.2016.11.004 22 HandelsmanD

As mice age, such protective effect may be lost due to higher pathology burden

Pol Arch Med Wewn (2008) 118(78):4205

Furthermore, increases in oxidative stress and nitrosative stress accompanied by an increase in total SOD activity have been observed in the muscles of COPD patients while they are at rest [16]