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Interestingly it was shown that mTORC1 upregulation leads to accumulation of fumarate, and contributes to tumor transformation

ACSS2-dependent histone acetylation improves cognition in mouse models of Alzheimers disease

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Campbell JA, Corrigall AV, Guy A, Kirsch RE (1991) Immunohistologic localization of alpha, Mu, and Pi class glutathione S-transferases in human tissues

For example, PAE not only protects against AS but also exerts neuroprotective effects by inhibiting neuronal ferroptosis in cerebral hemorrhage (Wei et al., 2023)