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2.1.2 NDDS developed based on different enzyme systems in the gastrointestinal tract The gastrointestinal tract harbors an intricate enzymatic network that functions as highly specialized molecular shears, cleaving chemical bonds in most pharmaceutical compounds and rendering them biologically inactive prior to reaching their target sites ( Chitosan is a linear polysaccharide formed by randomly distributed N-acetyl-D-glucosamine and D-glucosamine units connected by (14) glucoside bonds (Figure 2A)

Outside of genetic causes, copper has been found to be decreased in the Parkinsons disease brain corresponding to diminished cuproenzyme metallation and function linked to pathology 50,51,52,53,54

Adenosylcobalamin, the other active coenzyme form, supports mitochondrial energy production in neural tissue and may complement methylcobalamin in certain formulations