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15 Key Inflammatory Mediators Tumour necrosis factor-a (TNF-) TNF- is one of the major pro-inflammatory cytokines that is significantly increased in diabetic wounds Overexpression of TNF- inhibits fibroblast proliferation and collagen synthesis and stimulates apoptosis of endothelial cells and keratinocyte

Key Takeaway: Glutathione is the body's primary internal defense mechanism, but it requires a constant supply of "partner" antioxidants like vitamin C to remain in its active, reduced state

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