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Proc Natl Acad Sci 105:9499

Children with ASD commonly exhibit increased intestinal permeabilityoften referred to as leaky gutwhich allows microbial metabolites, such as short-chain fatty acids (SCFAs) and neuroactive compounds (e.g., 5-HT, GABA), to enter systemic circulation (Ullah et al., 2024)

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In conclusion, intestinal fungal dysregulation, mycobiome-derived metabolites, and the hosts antifungal immune response are key factors in the severity and prognosis of ALD, providing promising targets for future antifungal or immunomodulatory treatments

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