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Family physicians should consider screening patients who have any risk factors listed in Table 1

Analogously to the S168R and S217R human GnRHR mutants, the V 2 Rs with amino acid exchanges at the TMD2 and TMD4 interface (H80R, W164R, and S167L mutants) also showed recalcitrance to pharmacoperone treatment, most probably due to the severity of the folding defect as a consequence of the nature of the amino acid replacement (111, 195)

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If you follow a vegetarian or vegan diet, you may not be getting adequate amounts of this nutrient from the food you eat, which may put you at risk of a deficiency

Genomics 168 ZhangA