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As for the secondary outcome measures of gastrocnemius muscle mass and flexion foot contracture, there was a significant decrease in muscle mass seen in the right hind limb that underwent sciatic nerve transection, in comparison to the left hind limb that was not operated on

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While these methods help many patients, a significant percentage continue struggling with chronic pain that limits their quality of life for months or even years

Other peptides under investigation Several additional peptides are being studied for disc-related applications, though with less established evidence: Vasoactive Intestinal Peptide (VIP) has demonstrated the ability to slow disc degeneration progression and improve aggrecan levels in mouse studies

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