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The protective benefits of Mn porphyrins, including MnTM-2-pYp 5+ , MnTDE-2-ImP 5+ and MnTE-2-pYp 5+ , have been established in animal models of several diseases, including sickle cell disease [204], radiation induced injury [205], breast cancers [206], diabetes [207]

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This treatment significantly ameliorated doxorubicin-induced testicular weight loss, decreased sperm concentration and motility, and reduced abnormal sperm rates, ultimately attenuating doxorubicin-induced degenerative changes in seminiferous tubules