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Safety and dose escalation of the targeted oncolytic adenovirus OBP-301 for refractory advanced liver cancer: Phase I clinical trial

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The amplification program was carried out on a CFX96 instrument, and primers were designed on the based on NCBI data ( Table 1 )

Cytotoxin-associated gene A (CagA), a key virulence factor, undergoes phosphorylation by host c-Src/c-Abl kinases, activating oncogenic signaling pathways that induce gastric epithelial inflammation, precancerous lesions, and adenocarcinoma (Zhao et al., 2024)

Notably, lack of replication in publicly available datasets does not necessarily exclude biological relevance, particularly for variants that may be ancestry-specific or underpowered in prior studies