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Peripheral blood mononuclear cells (PBMC), isolated from total blood of PLWH, were treated with auranofin AF (500 nM), BSO (250 M) or a combination of the two, for 24 h

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Considering the pleiotropic subcellular localization and the essential role of the FeS-cluster-bearing enzymes in cell viability, it is easy to understand that faulty synthesis and lack of insertion of these inorganic elements can have detrimental effects on human health

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Dr Breeda Neville, Consultant in Public Health Medicine, HSE NCCP, said: Skin cancer is one of the fastest growing cancers in Ireland